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  Sister chromatid tension and the spindle assembly checkpoint

Nezi, L., & Musacchio, A. (2009). Sister chromatid tension and the spindle assembly checkpoint. CURRENT OPINION IN CELL BIOLOGY, 21(6), 785-795. doi:10.1016/j.ceb.2009.09.007.

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Nezi, Luigi1, Autor
Musacchio, Andrea2, Autor           
Affiliations:
1Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20139 Milan, Italy, ou_persistent22              
2Abt. I:Mechanistische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753287              

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 Zusammenfassung: The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response. On the contrary, lack of tension in the centromere-kinetochore region of sister chromatids has been shown to regulate a pathway of correction of undesired chromosome-microtubule connections, while the presence of tension is believed to promote the stabilization of attachments. We discuss how tension-sensitive phenomena, such as attachment correction and stabilization, relate to the SAC and we speculate on the existence of a single pathway linking error correction and SAC activation.

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 Datum: 2009
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: ISI: 000272936500011
DOI: 10.1016/j.ceb.2009.09.007
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Titel: CURRENT OPINION IN CELL BIOLOGY
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 21 (6) Artikelnummer: - Start- / Endseite: 785 - 795 Identifikator: ISSN: 0955-0674