English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Integrated Statistical Learning of Metabolic Ion Mobility Spectrometry Profiles for Pulmonary Disease Identification

Hauschild, A.-C., Baumbach, J. I., & Baumbach, J. (2012). Integrated Statistical Learning of Metabolic Ion Mobility Spectrometry Profiles for Pulmonary Disease Identification. Genetics and Molecular Research, 11(3), 2733-2744. doi:10.4238/2012.July.10.17.

Item is

Files

show Files

Locators

show
hide
Locator:
http://dx.doi.org/10.4238/2012.July.10.17 (Publisher version)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Hauschild, Anne-Christin1, Author           
Baumbach, Jörg Ingo2, Author
Baumbach, Jan1, Author           
Affiliations:
1Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society, ou_40046              
2External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Exhaled air carries information on human health status. Ion mobility spectrometers combined with a multi-capillary column (MCC/IMS) is a well-known technology for detecting volatile organic compounds (VOCs) within human breath. This technique is relatively inexpensive, robust and easy to use in every day practice. However, the potential of this methodology depends on successful application of computational approaches for finding relevant VOCs and classification of patients into disease-specific profile groups based on the detected VOCs. We developed an integrated state-of-the-art system using sophisticated statistical learning techniques for VOC-based feature selection and supervised classification into patient groups. We analyzed breath data from 84 volunteers, each of them either suffering from chronic obstructive pulmonary disease (COPD), or both COPD and bronchial carcinoma (COPD + BC), as well as from 35 healthy volunteers, comprising a control group (CG). We standardized and integrated several statistical learning methods to provide a broad overview of their potential for distinguishing the patient groups. We found that there is strong potential for separating MCC/IMS chromatograms of healthy controls and COPD patients (best accuracy COPD vs CG: 94). However, further examination of the impact of bronchial carcinoma on COPD/no-COPD classification performance is necessary (best accuracy CG vs COPD vs COPD + BC: 79). We also extracted 20 high-scoring VOCs that allowed differentiating COPD patients from healthy controls. We conclude that these statistical learning methods have a generally high accuracy when applied to wellstructured, medical MCC/IMS data.

Details

show
hide
Language(s): eng - English
 Dates: 2012-07-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.4238/2012.July.10.17
BibTex Citekey: Hauschild2012
PMID: 22869082
Other: Local-ID: A68C037B14AE615DC1257AF500554A14-Hauschild2012
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Genetics and Molecular Research
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Ribeirao Preto, SP, Brasil : FUNPEC
Pages: - Volume / Issue: 11 (3) Sequence Number: - Start / End Page: 2733 - 2744 Identifier: ISSN: 1676-5680