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  Recent Approaches to the Prioritization of Candidate Disease Genes

Doncheva, N. T., Kacprowski, T., & Albrecht, M. (2012). Recent Approaches to the Prioritization of Candidate Disease Genes. WIREs Systems Biology and Medicine, 4(5), 429-442. doi:10.1002/wsbm.1177.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-C52B-C Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-B45D-4
Genre: Zeitschriftenartikel

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 Urheber:
Doncheva, Nadezhda Tsankova1, Autor           
Kacprowski, Tim1, Autor           
Albrecht, Mario1, Autor           
Affiliations:
1Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society, ou_40046              

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Schlagwörter: -
 Zusammenfassung: Many efforts are still devoted to the discovery of genes involved with specific phenotypes, in particular, diseases. High-throughput techniques are thus applied frequently to detect dozens or even hundreds of candidate genes. However, the experimental validation of many candidates is often an expensive and time-consuming task. Therefore, a great variety of computational approaches has been developed to support the identification of the most promising candidates for follow-up studies. The biomedical knowledge already available about the disease of interest and related genes is commonly exploited to find new gene�disease associations and to prioritize candidates. In this review, we highlight recent methodological advances in this research field of candidate gene prioritization. We focus on approaches that use network information and integrate heterogeneous data sources. Furthermore, we discuss current benchmarking procedures for evaluating and comparing different prioritization methods.

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Sprache(n): eng - English
 Datum: 2012-06-11
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1002/wsbm.1177
BibTex Citekey: Albrecht2012c
Anderer: Local-ID: 76A8D4EB252E1DA8C1257AD8005C43C5-Albrecht2012c
PMID: 22689539
 Art des Abschluß: -

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Titel: WIREs Systems Biology and Medicine
  Kurztitel : Wiley Interdiscip Rev Syst Biol Med
  Andere : Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Chichester : Wiley
Seiten: - Band / Heft: 4 (5) Artikelnummer: - Start- / Endseite: 429 - 442 Identifikator: ISSN: 1939-005X