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  Direct experimental observation of the aggregation of α-amino acids into 100–200 nm clusters in aqueous solution

Hagmeier, D., Ruesing, J., Fenske, T., Klein, H.-W., Schmuck, C., Schrader, W., et al. (2012). Direct experimental observation of the aggregation of α-amino acids into 100–200 nm clusters in aqueous solution. RSC Advances, 2(11), 4690-4696. doi:10.1039/C2RA01352E.

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Hagmeier, Daniel1, Author
Ruesing, Johannes1, Author
Fenske, Tassilo2, Author
Klein, Heinz-Werner3, Author           
Schmuck, Carsten2, Author
Schrader, Wolfgang3, Author           
Minas da Piedade, Manuel E.4, Author
Epple, Matthias1, Author
Affiliations:
1Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117 Essen, Germany, ou_persistent22              
2Institute of Organic Chemistry and Center for Nanointegration Duisburg- Essen (CeNIDE), Universitaetsstr. 5-7, 45117 Essen, Germany, ou_persistent22              
3Service Department Schrader (MS), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445629              
4Centro de Química Bioquímica e Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal, ou_persistent22              

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 Abstract: Spherical supramolecular aggregates of α-amino acids with a typical diameter of 100–200 nm are formed spontaneously after dissolution in water at a concentration of a few mM, i.e. well below the solubility limit. Their presence was shown by nanoparticle tracking analysis (NTA), atomic force microscopy (AFM), and ESI mass spectrometry (ESI-MS). There is a dynamic equilibrium between the aggregates and dissolved individual molecules which allows them to penetrate through dialysis membranes and filters. The same phenomenon was observed for para-amino salicylic acid and two dipeptides. Thermodynamic considerations suggest an entropy-controlled process.

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Language(s): eng - English
 Dates: 2011-12-232012-03-142012-03-152012-06-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/C2RA01352E
 Degree: -

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Title: RSC Advances
  Abbreviation : RSC Adv.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 2 (11) Sequence Number: - Start / End Page: 4690 - 4696 Identifier: ISSN: 2046-2069
CoNE: https://pure.mpg.de/cone/journals/resource/2046-2069