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  Continuous biocatalytic synthesis of (R)-2-octanol with integrated product separation

Kohlmann, C., Leuchs, S., Greiner, L., & Leitner, W. (2011). Continuous biocatalytic synthesis of (R)-2-octanol with integrated product separation. Green Chemistry, 13(6), 1430-1436. doi:10.1039/c0gc00790k.

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 Creators:
Kohlmann, Christina1, Author
Leuchs, Susanne1, Author
Greiner, Lasse1, 2, Author
Leitner, Walter1, 3, Author           
Affiliations:
1Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, 52074, Aachen, Germany, ou_persistent22              
2DECHEMA e.V. Karl-Winnacker-Institut, Theodor-Heuss-Allee 25, 60486, Frankfurt am Main, Germany, ou_persistent22              
3Service Department Leitner (Technical Labs), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445626              

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 Abstract: The continuous biocatalytic synthesis of (R)-2-octanol carried out in an enzyme membrane reactor showed an excellent process stability of the biocatalysts, resulting in a turnover number of 15 million for the applied alcohol dehydrogenase. Utilisation of the ionic liquid AMMOENGTM 101 as a feasible cosolvent increased substrate concentration, and improved space time yields and turnover numbers of the cofactor by factors of 3 and 6, respectively. Moreover, 80% less waste was generated, while producing the same amount of product. Integrated product separation was realized via solid phase extraction. Extraction of the applied solid phase with supercritical carbon dioxide allowed more than 30 reuses of the solid phase.

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Language(s): eng - English
 Dates: 2010-11-092011-01-122011-02-152011-06-01
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/c0gc00790k
 Degree: -

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Title: Green Chemistry
  Other : Green Chem.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: 7 Volume / Issue: 13 (6) Sequence Number: - Start / End Page: 1430 - 1436 Identifier: ISSN: 1463-9262
CoNE: https://pure.mpg.de/cone/journals/resource/954925625301