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  Cognitive flexibility depends on white matter microstructure of the basal ganglia

Van Schouwenburg, M. R., Onnink, A. M. H., Ter Huurne, N., Kan, C. C., Zwiers, M. P., Hoogman, M., et al. (2014). Cognitive flexibility depends on white matter microstructure of the basal ganglia. Neuropsychologia, 53, 171-177. doi:10.1016/j.neuropsychologia.2013.11.015.

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Schouwenburg_etal_2014.pdf (Verlagsversion), 2MB
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2013
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Elsevier
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 Urheber:
Van Schouwenburg, Martine Rinske1, 2, 3, Autor
Onnink , A Marten H.1, Autor
Ter Huurne, Niels1, 2, Autor
Kan, Cees C.1, Autor
Zwiers, Marcel P.1, 2, Autor
Hoogman, Martine4, Autor           
Franke, Barbara1, 5, Autor
Buitelaar, Jan K.6, Autor
Cools, Roshan1, 2, Autor
Affiliations:
1Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Psychiatry, Nijmegen, NL, ou_persistent22              
2Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Nijmegen, NL, ou_persistent22              
3University of California, San Francisco, Department of Neurology, San Francisco, California, ou_persistent22              
4Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
5Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Human Genetics, Nijmegen, NL, ou_persistent22              
6Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, ou_persistent22              

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 Zusammenfassung: Ample evidence shows that the basal ganglia play an important role in cognitive flexibility. However, traditionally, cognitive processes have most commonly been associated with the prefrontal cortex. Indeed, current theoretical models of basal ganglia function suggest the basal ganglia interact with the prefrontal cortex and thalamus, via anatomical fronto-striato-thalamic circuits, to implement cognitive flexibility. Here we aimed to assess this hypothesis in humans by associating individual differences in cognitive flexibility with white matter microstructure of the basal ganglia. To this end we employed an attention switching paradigm in adults with ADHD and controls, leading to a broad range in task performance. Attention switching performance could be predicted based on individual differences in white matter microstructure in/around the basal ganglia. Crucially, local white matter showing this association projected to regions in the prefrontal cortex and thalamus. Our findings highlight the crucial role of the basal ganglia and the fronto-striato-thalamic circuit for cognitive flexibility.

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Sprache(n): eng - English
 Datum: 201320132014
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuropsychologia.2013.11.015
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Titel: Neuropsychologia
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 53 Artikelnummer: - Start- / Endseite: 171 - 177 Identifikator: ISSN: 0028-3932
CoNE: https://pure.mpg.de/cone/journals/resource/954925428258