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  The RNA exosome and proteasome: common principles of degradation control

Makino, D. L., Halbach, F., & Conti, E. (2013). The RNA exosome and proteasome: common principles of degradation control. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 14(10), 654-660. doi:10.1038/nrm3657.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-7885-D Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-C2D4-C
Genre: Zeitschriftenartikel

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 Urheber:
Makino, Debora L.1, Autor           
Halbach, Felix1, Autor           
Conti, Elena1, Autor           
Affiliations:
1Conti, Elena / Structural Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565144              

Inhalt

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Schlagwörter: HUMAN PM-SCL; NF-KAPPA-B; 26S PROTEASOME; RIBOSOMAL-RNA; 20S PROTEASOMES; YEAST EXOSOME; POLY(A) POLYMERASE; CRYSTAL-STRUCTURE; QUALITY-CONTROL; MULTICATALYTIC PROTEASE
 Zusammenfassung: Defective RNAs and proteins are swiftly degraded by cellular quality control mechanisms. A large fraction of their degradation is mediated by the exosome and the proteasome. These complexes have a similar architectural framework based on cylindrical, hollow structures that are conserved from bacteria and archaea to eukaryotes. Mechanistic similarities have also been identified for how RNAs and proteins are channelled into these structures and prepared for degradation. Insights gained from studies of the proteasome should now set the stage for elucidating the regulation, assembly and small-molecule inhibition of the exosome.

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Sprache(n): eng - English
 Datum: 2013-10
 Publikationsstatus: Erschienen
 Seiten: 7
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000324810500014
DOI: 10.1038/nrm3657
 Art des Abschluß: -

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Titel: NATURE REVIEWS MOLECULAR CELL BIOLOGY
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Seiten: - Band / Heft: 14 (10) Artikelnummer: - Start- / Endseite: 654 - 660 Identifikator: ISSN: 1471-0072