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Free keywords:
atom economy; C[BOND]H activation; C[BOND]H functionalization; hydride transfer; redox chemistry
Abstract:
The direct functionalization of C[BOND]H bonds is an attractive strategy in organic synthesis. Although several advances have been made in this area, the selective activation of inert sp3 C[BOND]H bonds remains a daunting challenge. Recently, a new type of sp3 C[BOND]H activation mode through internal hydride transfer has demonstrated the potential to activate remote sp3 C[BOND]H linkages in an atom-economic manner. This Minireview attempts to classify recent advances in this area including the transition to non-activated sp3 C[BOND]H bonds and asymmetric hydride transfers.
