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  Different sequence signatures in the upstream regions of plant and animal tRNA genes shape distinct modes of regulation

Zhang, G., Lukoszek, R., Mueller-Roeber, B., & Ignatova, Z. (2011). Different sequence signatures in the upstream regions of plant and animal tRNA genes shape distinct modes of regulation. Nucleic Acids Research, 39(8), 3331-3339. doi:10.1093/Nar/Gkq1257.

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Zhang, G.1, Autor
Lukoszek, R.1, Autor
Mueller-Roeber, B.1, Autor           
Ignatova, Z.1, Autor
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1External Organizations, ou_persistent22              

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Schlagwörter: polymerase-iii transcription tata box saccharomyces-cerevisiae promoter elements nuclear regulator genomic sequence ternary complex DNA complexes factor tfiiib in-vitro
 Zusammenfassung: In eukaryotes, the transcription of tRNA genes is initiated by the concerted action of transcription factors IIIC (TFIIIC) and IIIB (TFIIIB) which direct the recruitment of polymerase III. While TFIIIC recognizes highly conserved, intragenic promoter elements, TFIIIB binds to the non-coding 5'-upstream regions of the tRNA genes. Using a systematic bioinformatic analysis of 11 multicellular eukaryotic genomes we identified a highly conserved TATA motif followed by a CAA-motif in the tRNA upstream regions of all plant genomes. Strikingly, the 5'-flanking tRNA regions of the animal genomes are highly heterogeneous and lack a common conserved sequence signature. Interestingly, in the animal genomes the tRNA species that read the same codon share conserved motifs in their upstream regions. Deep-sequencing analysis of 16 human tissues revealed multiple splicing variants of two of the TFIIIB subunits, Bdp1 and Brf1, with tissue-specific expression patterns. These multiple forms most likely modulate the TFIIIB-DNA interactions and explain the lack of a uniform signature motif in the tRNA upstream regions of animal genomes. The anticodon-dependent 5'-flanking motifs provide a possible mechanism for independent regulation of the tRNA transcription in various human tissues.

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Sprache(n): eng - English
 Datum: 2010-12-072011
 Publikationsstatus: Erschienen
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 Identifikatoren: ISI: ISI:000290055200033
DOI: 10.1093/Nar/Gkq1257
ISSN: 0305-1048
URI: ://000290055200033 http://nar.oxfordjournals.org/content/39/8/3331.full.pdf#page=1&view=FitH
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Titel: Nucleic Acids Research
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 39 (8) Artikelnummer: - Start- / Endseite: 3331 - 3339 Identifikator: -