New indene-derivatives with anti-proliferative properties

Karaguni, Ioanna-Maria; Glusenkamp, Karl-Heinz; Langerak, Anette; Geisen, Christoph; Ullrich, Volker; Winde, Günther; Möröy, Tarik; Müller, Oliver

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New indene-derivatives with anti-proliferative properties

Karaguni, I.-M., Glusenkamp, K.-H., Langerak, A., Geisen, C., Ullrich, V., Winde, G., et al. (2002). New indene-derivatives with anti-proliferative properties. Bioorganic & Medicinal Chemistry Letters, 12(4): 1, pp. 709-713. Retrieved from http://dx.doi.org/10.1016/S0960-894X(01)00839-3.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-0EE1-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-0EE2-E

Genre: Journal Article

Alternative Title : Bioorg. Med. Chem. Lett.

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Creators:
Karaguni, Ioanna-Maria¹, Author
Glusenkamp, Karl-Heinz, Author
Langerak, Anette¹, Author
Geisen, Christoph, Author
Ullrich, Volker, Author
Winde, Günther, Author
Möröy, Tarik, Author
Müller, Oliver², Author

Affiliations:
1Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753286
2Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753294

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Abstract: Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein. (C) 2002 Elsevier Science Ltd. All rights reserved.

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Language(s): eng - English

Dates: Date issued: 2002-02-25

Publication Status: Issued

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Rev. Type: Peer

Identifiers: eDoc: 12932
URI: http://dx.doi.org/10.1016/S0960-894X(01)00839-3

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Title: Bioorganic & Medicinal Chemistry Letters

Alternative Title : Bioorg. Med. Chem. Lett.

Source Genre: Journal

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Pages: - Volume / Issue: 12 (4) Sequence Number: 1 Start / End Page: 709 - 713 Identifier: -