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  Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B

Ludolph, B., Eisele, F., & Waldmann, H. (2002). Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B. ChemBioChem, 3(9): 1, pp. 901-904. Retrieved from http://dx.doi.org/10.1002/1439-7633(20020902)3:9<901:AID-CBIC901>3.0.CO;2-U.

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Genre: Journal Article
Alternative Title : Chembiochem

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 Creators:
Ludolph, Björn1, Author
Eisele, Frank, Author
Waldmann, Herbert2, Author           
Affiliations:
1Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753286              
2Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753290              

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Free keywords: lipopetides; lipoproteins; solid-phase synthesis; Ras proteins; Rho proteins
 Abstract: Phasing the problem: Polybasic, farnesylated, and fluorescence- or biotin-tagged K-Ras 4B (1) and Rho A peptides can be efficiently synthesized in solution or on a solid support by employment of a combination of Fmoc and Aloc urethanes with trityl groups and a trityl linker. The synthesis methods described in both solid and solution phases present new opportunities for future investigation of areas such as membrane targeting by Ras, Rho, and related lipidated proteins. Biot = biotin, Aca = aminocaproic acid.

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Language(s): eng - English
 Dates: 2002-09-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: ChemBioChem
  Alternative Title : Chembiochem
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 3 (9) Sequence Number: 1 Start / End Page: 901 - 904 Identifier: -