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  Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex

Gordeliy, V. I., Labahn, J., Moukhametzianov, R., Efremov, R., Granzin, J., Schlesinger, R., et al. (2002). Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex. Nature, 419(6906): 1, pp. 484-487. Retrieved from http://dx.doi.org/10.1038/nature01109.

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Genre: Journal Article
Alternative Title : Nature

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Gordeliy, Valentin I., Author
Labahn, Jörg, Author
Moukhametzianov, Rouslan, Author
Efremov, Rouslan, Author
Granzin, Joachim, Author
Schlesinger, Ramona, Author
Büldt, Georg, Author
Savopol, Tudor1, Author
Scheidig, Axel J.2, Author           
Klare, Johann P.1, Author
Engelhard, Martin2, Author           
Affiliations:
1Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753286              
2Abt. III: Physikalische Biochemie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753289              

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 Abstract: Microbial rhodopsins, which constitute a family of seven-helix membrane proteins with retinal as a prosthetic group, are distributed throughout the Bacteria, Archaea and Eukaryota(1- 3). This family of photoactive proteins uses a common structural design for two distinct functions: light-driven ion transport and phototaxis. The sensors activate a signal transduction chain similar to that of the two-component system of eubacterial chemotaxis(4). The link between the photoreceptor and the following cytoplasmic signal cascade is formed by a transducer molecule that binds tightly and specifically 5 to its cognate receptor by means of two transmembrane helices (TM1 and TM2). It is thought that light excitation of sensory rhodopsin II from Natronobacterium pharaonis (SRII) in complex with its transducer (HtrII) induces an outward movement of its helix F (ref. 6), which in turn triggers a rotation of TM2 (ref. 7). It is unclear how this TM2 transition is converted into a cellular signal. Here we present the X-ray structure of the complex between N. pharaonis SRII and the receptor-binding domain of HtrII at 1.94 Angstrom resolution, which provides an atomic picture of the first signal transduction step. Our results provide evidence for a common mechanism for this process in phototaxis and chemotaxis.

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Language(s): eng - English
 Dates: 2002-10-01
 Publication Status: Issued
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 14258
URI: http://dx.doi.org/10.1038/nature01109
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Title: Nature
  Alternative Title : Nature
Source Genre: Journal
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Pages: - Volume / Issue: 419 (6906) Sequence Number: 1 Start / End Page: 484 - 487 Identifier: -