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  Dissecting medial temporal lobe contributions to item and associative memory formation

Qin, S., Rijpkema, M., Tendolkar, I., Piekema, C., Hermans, E. J., Binder, M., et al. (2009). Dissecting medial temporal lobe contributions to item and associative memory formation. NeuroImage, 46, 874-881. doi:10.1016/j.neuroimage.2009.02.039.

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Qin_NeuroImage_2009.pdf (Verlagsversion), 652KB
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Qin, Shaozheng1, 2, 3, Autor
Rijpkema, Mark 1, Autor
Tendolkar, Indira 4, Autor
Piekema, Carinne 1, Autor
Hermans, Erno J. 1, Autor
Binder, Marek 5, Autor
Petersson, Karl Magnus1, Autor           
Luo, Jing3, Autor
Fernández, Guillén 1, 2, Autor
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
2Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands, ou_persistent22              
3Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences (CAS),Beijing, China, ou_persistent22              
4Department of Psychiatry, Radboud University Nijmegen Medical Center,Nijmegen, The Netherlands, ou_persistent22              
5Psychophysiology Unit, Jagiellonian University, Cracow, Poland, ou_persistent22              

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Schlagwörter: Episodic memory Hippocampus Parahippocampal cortex Perirhinal cortex Prefrontal cortex
 Zusammenfassung: A fundamental and intensively discussed question is whether medial temporal lobe (MTL) processes that lead to non-associative item memories differ in their anatomical substrate from processes underlying associative memory formation. Using event-related functional magnetic resonance imaging, we implemented a novel design to dissociate brain activity related to item and associative memory formation not only by subsequent memory performance and anatomy but also in time, because the two constituents of each pair to be memorized were presented sequentially with an intra-pair delay of several seconds. Furthermore, the design enabled us to reduce potential differences in memory strength between item and associative memory by increasing task difficulty in the item recognition memory test. Confidence ratings for correct item recognition for both constituents did not differ between trials in which only item memory was correct and trials in which item and associative memory were correct. Specific subsequent memory analyses for item and associative memory formation revealed brain activity that appears selectively related to item memory formation in the posterior inferior temporal, posterior parahippocampal, and perirhinal cortices. In contrast, hippocampal and inferior prefrontal activity predicted successful retrieval of newly formed inter-item associations. Our findings therefore suggest that different MTL subregions indeed play distinct roles in the formation of item memory and inter-item associative memory as expected by several dual process models of the MTL memory system.

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Sprache(n): eng - English
 Datum: 2009
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2009.02.039
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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 46 Artikelnummer: - Start- / Endseite: 874 - 881 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166