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Abstract:
A role for the Pax-6 homologue eyeless in adult Drosophila brain development and function is described. eyeless expression is detected in
neurons, but not glial cells, of the mushroom bodies, the medullar cortex, the lateral horn, and the pars intercerebralis. Furthermore, severe defects in adult
brain structures essential for vision, olfaction, and for the coordination of locomotion are provoked by two newly isolated mutations of Pax-6/eyeless that
result in truncated proteins. Consistent with the morphological lesions, we observe defective walking behavior for these eyeless mutants. The implications of
these data for understanding postembryonic brain development and function in Drosophila are discussed.
