Frontocortical N-acetylaspartate reduction associated with long-term IV heroin 
use

Haselhorst, R; Dürsteler-MacFarland KM, Scheffler, K; Ladewig D, Müller-Spahn F, Stohler R, Seelig, J; Seifritz, E

doi:10.1212/WNL.58.2.305

Item

ITEM ACTIONSEXPORT

DownloadE-Mail

Please note that a newer version of this item is available:
https://pure.mpg.de/pubman/item/item_1792940_2

DetailsSummary

Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use

Haselhorst, R., Dürsteler-MacFarland KM, Scheffler, K., Ladewig D, Müller-Spahn F, Stohler R, Seelig, J., & Seifritz, E. (2002). Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use. Neurology, 58(2), 305-307. doi:10.1212/WNL.58.2.305.

Item is Released

show all hide all

Basic

show hide

Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-E064-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-E065-3

Genre: Journal Article

Files

show Files

Locators

show

Creators

show

hide

Creators:
Haselhorst, R, Author
Dürsteler-MacFarland KM, Scheffler, K¹, Author
Ladewig D, Müller-Spahn F, Stohler R, Seelig, J, Author
Seifritz, E, Author

Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796

Content

show

hide

Free keywords: -

Abstract: To examine possible metabolic frontal lobe alterations in IV heroin-dependent patients with different histories of concomitant substance use, N-acetylaspartate (NAA), a putative marker of neuronal viability, was measured by 1H-MRS. Compared with controls, NAA levels in patients were reduced by 7 in gray matter (p = 0.015) but not in white matter. To what extent comorbid conditions or substance use, including alcohol, contributed to these frontocortical metabolic changes remains to be elucidated.

Details

show

hide

Language(s):

Dates: Date issued: 2002-01

Publication Status: Issued

Pages: -

Publishing info: -

Table of Contents: -

Rev. Type: -

Identifiers: URI: http://www.neurology.org/content/58/2/305.abstract
DOI: 10.1212/WNL.58.2.305
BibTex Citekey: HaselhorstDSLMSSS2002

Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show

hide

Title: Neurology

Source Genre: Journal

Creator(s):

Affiliations:

Publ. Info: -

Pages: - Volume / Issue: 58 (2) Sequence Number: - Start / End Page: 305 - 307 Identifier: -