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Zusammenfassung:
Non-linearities in the measured BOLD data were found for the response integral and width. With the high sensitivity at 7T, a voxel-based analysis was feasible and was used to investigate the spatial dependence of the non-linearities at high spatial resolution. Correlation between response onset and non-linearity suggests that the origin of the observations are a tissue-specific phenomenon. Comparison with 4T and 1.5T data also indicates a field dependence. The observed non-linearity at short stimulus duration (SD) has likely a considerable hemodynamic contribution and thus must be accounted for in event-related fMRI paradigms.