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  Lack of long-term cortical reorganization after macaque retinal lesions

Smirnakis, S., Brewer AA, Schmid, M., Tolias, A., Schüz, A., Augath, M., Inhoffen W, Wandell, B., et al. (2005). Lack of long-term cortical reorganization after macaque retinal lesions. Nature, 435(7040), 300-307. doi:10.1038/nature03495.

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Smirnakis, SM1, Author           
Brewer AA, Schmid, MC2, Author           
Tolias, AS2, Author           
Schüz, A2, Author           
Augath, M2, Author           
Inhoffen W, Wandell, BA, Author
Logothetis, NK2, Author           
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Several aspects of cortical organization are thought to remain plastic into adulthood, allowing cortical sensorimotor maps to be modified continuously by experience. This dynamic nature of cortical circuitry is important for learning, as well as for repair after injury to the nervous system. Electrophysiology studies suggest that adult macaque primary visual cortex (V1) undergoes large-scale reorganization within a few months after retinal lesioning, but this issue has not been conclusively settled. Here we applied the technique of functional magnetic resonance imaging (fMRI) to detect changes in the cortical topography of macaque area V1 after binocular retinal lesions. fMRI allows non-invasive, in vivo, long-term monitoring of cortical activity with a wide field of view, sampling signals from multiple neurons per unit cortical area. We show that, in contrast with previous studies, adult macaque V1 does not approach normal responsivity during 7.5 months of follow-up after retinal lesions, and its topography does not change. Electrophysiology experiments corroborated the fMRI results. This indicates that adult macaque V1 has limited potential for reorganization in the months following retinal injury.

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 Dates: 2005-05
 Publication Status: Issued
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Title: Nature
Source Genre: Journal
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Pages: - Volume / Issue: 435 (7040) Sequence Number: - Start / End Page: 300 - 307 Identifier: -