English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  On the Kinetic Design of Transcription

Höfer, T., & Rasch, M. (2005). On the Kinetic Design of Transcription. Genome Informatics, 16(1), 73. Retrieved from http://www.jsbi.org/journal/IBSB05/IBSB05F020.html.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Höfer, T, Author
Rasch, MJ1, Author           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

Content

show
hide
Free keywords: -
 Abstract: We analyse a stochastic model of transcription that describes transcription initiation by promoter activation and subsequent polymerase recruitment. Explicit expressions are derived for the control of an activator on the mean mRNA number and for the mRNA noise. Both properties are strongly influenced by the kinetics of promoter activation, mRNA synthesis and degradation. Low transcriptional noise is obtained either when the transcription initiation complex has a long life-time or when its components associate and dissociate rapidly. However, the ability of an activator to regulate the mRNA level is low in the first and high in the second case. Large noise is generated when the initial activation step of the promoter is slow. In this case, transcription can be burst-like; the mRNA distribution becomes bimodal while regulability of the mean copy number is maintained.

Details

show
hide
Language(s):
 Dates: 2005-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: URI: http://www.jsbi.org/journal/IBSB05/IBSB05F020.html
BibTex Citekey: 4701
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Genome Informatics
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 16 (1) Sequence Number: - Start / End Page: 73 Identifier: -