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  Determination of tiopronin in human plasma by HPLC-MS with precolumn derivatization.

Li, J., Bi, S., & Chen, H. (2006). Determination of tiopronin in human plasma by HPLC-MS with precolumn derivatization. Chinese Journal of New Drugs and Clinical Remedies., 25(6), 421-423.

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Li, J1, Author           
Bi, SK, Author
Chen, HX, Author
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1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Tiopronin (2-mercaptopropionylglycine, TP) is a thiol compound, which has been used as a hepatoprotective and anti-cataract agent. It also modifies rheumatoid arthritis and has been applied in the treatment of cystinuria. In this study, a sensitive and reproducible HPLC-MS method has been developed for the analysis of tiopronin in human plasma. Pre-column derivatization with 2, 4-dinitrofluorobenzene (DNCB), the blood plasma was de-proteinized and purified by liquid-liquid extraction. This assay method was successively applied to a pharmacokinetics study.

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 Dates: 2006-01
 Publication Status: Issued
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 Identifiers: BibTex Citekey: 6176
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Title: Chinese Journal of New Drugs and Clinical Remedies.
Source Genre: Journal
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Pages: - Volume / Issue: 25 (6) Sequence Number: - Start / End Page: 421 - 423 Identifier: -