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  Intracellular MR Contrast Agents Based on Cationic Cell Penetrating Peptides: A Comparative Study

Engelmann, J., Su, W., Jha, D., Mishra, R., Pfeuffer, J., & Ugurbil, K. (2006). Intracellular MR Contrast Agents Based on Cationic Cell Penetrating Peptides: A Comparative Study. Poster presented at 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA, USA.

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 Creators:
Engelmann, J1, Author           
Su, W1, Author           
Jha, D1, Author           
Mishra, R1, Author           
Pfeuffer, J2, Author           
Ugurbil, K, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: For the development of intracellular Magnetic Resonance contrast agents (CAs) it is a prerequisite that they cross the plasma membrane. Cell penetrating peptides (CPPs) are known to transport cargo molecules attached to it into cells. We synthesized intracellular CAs containing known CPPs or modified peptides. Gd-diethylenetriaminepenta-acetic acid (Gd-DTPA) was coupled to CPPs for MR visualization and fluorescence imaging agent fluorescein isothiocyanate (FITC) for tracking the agent inside cells by optical imaging. Compared on the basis of these measurements, modifications in CPPs enhanced the intracellular delivery ability of our CAs providing a tool for stable labeling of cells for MR imaging.

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 Dates: 2006-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: URI: http://www.ismrm.org/06/
BibTex Citekey: 5140
 Degree: -

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Title: 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006)
Place of Event: Seattle, WA, USA
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