English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Metabolic Characterization of Patients with Alcoholic and Non-Alcoholic Steatohepatitis

Gottschalk, S., Hohnholt M, Bilodeau M, Leibfritz, D., & Zwingmann, C. (2007). Metabolic Characterization of Patients with Alcoholic and Non-Alcoholic Steatohepatitis. Poster presented at 2007 Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Gottschalk, S1, Author           
Hohnholt M, Bilodeau M, Leibfritz, D, Author
Zwingmann, C, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

Content

show
hide
Free keywords: -
 Abstract: Liver steatosis is an increasingly common cause of liver diseases. Today it is still difficult to differentiate patients with non-alcoholic steatohepatitis (NASH) from patients with alcoholic steatohepatitis (ASH) on the basis of clinical and biochemical evaluations. Since it is becoming urgent to develop new diagnostic methods for NASH, we applied high-resolution 1H- and (natural abundance) 13C-NMR spectroscopy to detect metabolic profiles in preparations of blood and urine in patients with NASH and ASH. 1H- and 13C-NMR spectra of urine and blood samples showed considerable and reproducible differences in specific metabolites involved in intermediary as well as lipid metabolism in patients with NASH and ASH compared to healthy controls. The results demonstrate that NMR applications on human body fluids are of great potential to characterize NASH, a disease displaying multiple interrelated metabolic factors. This approach could provide noninvasively data to characterize steatosis and give the possibility to distinguish between NASH and ASH.

Details

show
hide
Language(s):
 Dates: 2007-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: URI: http://www.ismrm.org/07/
BibTex Citekey: GottschalkHBLZ2007
 Degree: -

Event

show
hide
Title: 2007 Joint Annual Meeting ISMRM-ESMRMB
Place of Event: Berlin, Germany
Start-/End Date: -

Legal Case

show

Project information

show

Source

show