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  Synthesis and Relaxation Properties of Three Novel Bis-macrocycles: Attempt towards Calcium Sensitive MRI Contrast Agents

Mishra, A., Fousková P, Balogh E, Angelovski, G., Logothetis, N., & Tóth, É. (2007). Synthesis and Relaxation Properties of Three Novel Bis-macrocycles: Attempt towards Calcium Sensitive MRI Contrast Agents. Poster presented at AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.

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 Urheber:
Mishra, A1, Autor           
Fousková P, Balogh E, Angelovski, G1, Autor           
Logothetis, NK1, Autor           
Tóth, É, Autor
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1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Zusammenfassung: MR contrast agents whose efficiency depends on the concentration of signaling molecules may be used to directly visualize neuronal activation. The so-called ‘smart’ contrast agents for magnetic resonance imaging exhibit dynamic and reversible modulation of their relaxivity by specific physiological or biochemical triggers such as changes in pH, Ca2+ concentration or enzymatic activity. The extracellular concentration of Ca2+ plays an important role in the physiological and pathological processes of the nervous system; it led us to design chelating systems in which the relaxivity is influenced by the Ca2+ concentration. We synthesized three novel bifunctional bismacrocycles based on DO3A-EA coupled to EDTA/DTPA-bisanhydride via amide bonds.

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 Datum: 2007-09
 Publikationsstatus: Erschienen
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Titel: AMI/SMI Joint Molecular Imaging Conference 2007
Veranstaltungsort: Providence, RI, USA
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