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  Protein Functional Class Prediction With a Combined Graph

Shin, H., Tsuda, K., & Schölkopf, B. (2008). Protein Functional Class Prediction With a Combined Graph. Expert Systems with Applications, 36(2), 3284-3292. doi:10.1016/j.eswa.2008.01.006.

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Shin, HH1, Autor           
Tsuda, K1, Autor           
Schölkopf, B1, Autor           
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              

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 Zusammenfassung: In bioinformatics, there exist multiple descriptions of graphs for the same set of genes or proteins. For instance, in yeast systems, graph edges can represent different relationships such as protein–protein interactions, genetic interactions, or co-participation in a protein complex, etc. Relying on similarities between nodes, each graph can be used independently for prediction of protein function. However, since different graphs contain partly independent and partly complementary information about the problem at hand, one can enhance the total information extracted by combining all graphs. In this paper, we propose a method for integrating multiple graphs within a framework of semi-supervised learning. The method alternates between minimizing the objective function with respect to network output and with respect to combining weights. We apply the method to the task of protein functional class prediction in yeast. The proposed method performs significantly better than the same algorithm trained on any singl e graph.

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 Datum: 2008-03
 Publikationsstatus: Erschienen
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Titel: Expert Systems with Applications
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 36 (2) Artikelnummer: - Start- / Endseite: 3284 - 3292 Identifikator: -