Liver tissue repair in a mouse model of toxicant-induced liver inury is 
associated with increased hepatic energy metabolism

Gottschalk, S; Leibfritz D, Zwingmann, C; Bilodeau, M

Item

ITEM ACTIONSEXPORT

Add to Basket

Please note that a newer version of this item is available:
https://pure.mpg.de/pubman/item/item_1789428_3

DetailsSummary

Liver tissue repair in a mouse model of toxicant-induced liver inury is associated with increased hepatic energy metabolism

Gottschalk, S., Leibfritz D, Zwingmann, C., & Bilodeau, M. (2009). Liver tissue repair in a mouse model of toxicant-induced liver inury is associated with increased hepatic energy metabolism. Poster presented at 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009), Honolulu, HI, USA.

Item is Released

show all hide all

Basic

show hide

Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-C565-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-C566-A

Genre: Poster

Files

show Files

Locators

show

Creators

show

hide

Creators:
Gottschalk, S¹, Author
Leibfritz D, Zwingmann, C, Author
Bilodeau, M, Author

Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796

Content

show

hide

Free keywords: -

Abstract: Due to its ability regenerate, the liver is an ideal model for studying tissue repair mechanisms. Only little is known about the repair-associated changes in cellular metabolic pathways. Energy-intensive repair processes should be reflected in alterations in energy metabolism. An in vivo liver-injury model was used to generate an onset of liver tissue-repair. We assessed the extent of liver-injury and NMR-spectroscopy was used to characterize changes in energy metabolism and metabolites. Our results showed that induction of liver-regeneration was consistent with an up-regulation of the cells overall energy metabolism and a higher demand for TCA-cycle intermediates (eg. for amino-acids synthesis).

Details

show

hide

Language(s):

Dates: Date issued: 2009-04

Publication Status: Issued

Pages: -

Publishing info: -

Table of Contents: -

Rev. Type: -

Identifiers: URI: http://www.ismrm.org/09/
BibTex Citekey: GottschalkLZB2009

Degree: -

Event

show

hide

Title: 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009)

Place of Event: Honolulu, HI, USA

Start-/End Date: -

Legal Case

show

Project information

show

Source

show