Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  The GD box: A widespread non-contiguous supersecondary structural element

Alva, V., Dunin-Horkawicz S, Habeck, M., Coles, M., & Lupas, A. (2009). The GD box: A widespread non-contiguous supersecondary structural element. Protein Science, 18(9), 1961-1966. doi:10.1002/pro.207.

Item is

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Alva, V, Autor
Dunin-Horkawicz S, Habeck, M1, Autor           
Coles, M, Autor
Lupas, AN, Autor
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Identification and characterization of recurrent supersecondary structural elements is central to understanding the rules governing protein tertiary structure. Here we describe the GD box, a widespread non-contiguous supersecondary element, which we initially found in a group of topologically distinct but homologous beta-barrels - the cradle-loop barrels. The GD box is similar both in sequence and structure and comprises two short unpaired beta-strands connected by an orthogonal type-II beta-turn and a non-contiguous beta-strand forming hydrogen bonds with the beta-turn. Using structure-based analysis, we have detected 518 instances of the GD box in a non-redundant subset of the SCOP database comprising 3771 domains. Apart from the cradle-loop barrels, this motif is also found in a diverse set of non-homologous folds including other topologically related beta-barrels. Since non-local interactions are fundamental in the formation of protein structure, systematic identification and characterization of other non -contiguous supersecondary structural elements is likely to prove valuable to protein structure modeling, validation, and prediction.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2009-07
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: URI: http://www3.interscience.wiley.com/journal/122513699/abstract
DOI: 10.1002/pro.207
BibTex Citekey: 5941
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Protein Science
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 18 (9) Artikelnummer: - Start- / Endseite: 1961 - 1966 Identifikator: -