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Abstract:
Since the small animal imaging generally requires anesthesia, anesthetic agents can induce unintended effects on animal physiology that may
confound the results of imaging studies [1]. The use of isoflurane and ketamine/xylazine anesthesia is popular in imaging studies of laboratory
animals. The striatum is the major input station of the basal ganglia system. It is involved in Parkinson's disease, Huntington’s disease, choreas,
choreoathetosis and dyskinesias [2]. Recently, 1H-MRS studies of common and severe neuropsychiatric disorders (e.g., obsessive-compulsive
disorder, schizophrenia, etc.) have reported abnormal metabolite levels in the striatum (cudate and putamen nuclei) [3]. The purpose of this study
was to evaluate alterations in striatum metabolites of rats between anesthetized with isoflurane and with ketamine/xylazine in proton magnetic
resonance spectroscopy (1H-MRS), and to investigate the appropriateness of anesthetic agents for 1H-MRS study.
