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  In-vivo assessment of tissue metabolite levels using 1H MRS and the Electric REference To access In vivo Concentrations (ERETIC) method

Heinzer-Schweizer, S., De Zanche N, Pavan M, Mens G, Sturzenegger U, Henning, A., & Boesiger, P. (2010). In-vivo assessment of tissue metabolite levels using 1H MRS and the Electric REference To access In vivo Concentrations (ERETIC) method. NMR in Biomedicine, 23(4), 406–413. doi:10.1002/nbm.1476.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-C01E-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-C01F-3
Genre: Journal Article

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Heinzer-Schweizer, S, Author
De Zanche N, Pavan M, Mens G, Sturzenegger U, Henning, A1, Author           
Boesiger, P, Author
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1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Quantitative values of metabolite concentrations in 1H magnetic resonance spectroscopy have been obtained using the Electric REference To access Invivo Concentrations (ERETIC) method, whereby a synthetic reference signal is injected during the acquisition of spectra. The method has been improved to enable quantification of metabolite concentrations invivo. Optical signal transmission was used to eliminate random fluctuations in ERETIC signal coupling to the receiver coil due to changes in position of cables and highly dielectric human tissue. Stability and reliability of the signal were tested in vitro, achieving stability with a mean error of 2.83. Scaling of the signal in variable loading conditions was demonstrated and in-vivo measurements of brain were acquired on a 3T Philips system using a transmit/receive coil. The quantitative brain water and metabolite concentration values are in good agreement with those in the literature.

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 Dates: 2010-05
 Publication Status: Issued
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 Identifiers: URI: http://onlinelibrary.wiley.com/doi/10.1002/nbm.1476/pdf
DOI: 10.1002/nbm.1476
BibTex Citekey: HeinzerSchweizerDPMSHB2010
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Title: NMR in Biomedicine
Source Genre: Journal
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Pages: - Volume / Issue: 23 (4) Sequence Number: - Start / End Page: 406–413 Identifier: -