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  Quantification of fat infiltration in oculopharyngeal muscular dystrophy: Comparison of three MR imaging methods

Gloor, M., Fasler S, Fischmann A, Haas T, Bieri O, Heinimann K, Wetzel SG, Scheffler, K., & Fischer, D. (2011). Quantification of fat infiltration in oculopharyngeal muscular dystrophy: Comparison of three MR imaging methods. Journal of Magnetic Resonance Imaging, 33(1), 203-210. doi:10.1002/jmri.22431.

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Gloor, M, Autor
Fasler S, Fischmann A, Haas T, Bieri O, Heinimann K, Wetzel SG, Scheffler, K1, Autor           
Fischer, D, Autor
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1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Zusammenfassung: Purpose To analyze and compare three quantitative MRI methods to determine the degree of muscle involvement in oculopharyngeal muscular dystrophy (OPMD). Materials and Methods Muscle fat content (MFC) was determined based on water–fat quantification using a 2-point Dixon (2PD) method and on a histogram analysis of the free induction decay (FID) signal of a gradient-spoiled steady-state free precession (SSFP) sequence. In addition, transverse relaxation times (T2) of muscle tissue were calculated using a monoexponential decay model. Results We observed an increased mean MFC in OPMD patients as compared to healthy controls with the adductor magnus and soleus muscles being the most involved muscles in the thigh and calf, respectively. Furthermore, strong correlations (0.78 < R2 < 0.94) between different quantitative MR methods were observed. Fewer outliers, however, were obtained by the 2PD method and T2 measurements, suggesting these methods being superior to the SSFP-FID method. Conclusion Quantitative MR techniques, such as fast multiecho Dixon methods and T2 imaging, can reliably differentiate between healthy and dystrophic muscles in OPMD, even if muscles are only marginally affected. Quantitative methods thus represent a promising tool that may be able to monitor more objectively the individual disease progression and treatment response in future clinical trials in muscular dystrophies.

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 Datum: 2011-01
 Publikationsstatus: Erschienen
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 Identifikatoren: URI: http://onlinelibrary.wiley.com/doi/10.1002/jmri.22431/pdf
DOI: 10.1002/jmri.22431
BibTex Citekey: GloorFFHBHWSF2011
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Titel: Journal of Magnetic Resonance Imaging
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 33 (1) Artikelnummer: - Start- / Endseite: 203 - 210 Identifikator: -