A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool 
for detection of enzymes

Keliris, A; Mamedov, I; Hagberg, GE; Logothetis, NK; Scheffler, K; Engelmann, J

doi:10.1002/cmmi.1470

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A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes

Keliris, A., Mamedov, I., Hagberg, G., Logothetis, N., Scheffler, K., & Engelmann, J. (2012). A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes. Contrast Media and Molecular Imaging, 7(5), 478–483. doi:10.1002/cmmi.1470.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-B612-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-B613-E

Genre: Journal Article

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Creators:
Keliris, A¹, Author
Mamedov, I², Author
Hagberg, GE^{1, 2}, Author
Logothetis, NK², Author
Scheffler, K¹, Author
Engelmann, J¹, Author

Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798

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Abstract: Here we report on a dual-modal 19F and 1H MRI paramagnetic probe with a self-immolative linker, Gd–DOMF–Gal. The enzymatic conversion of this probe by β-galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd3+ complex to modulate the 1H MR signal intensity of the surrounding water molecules. A versatile imaging platform for monitoring a variety of enzymes by 19F and 1H MRI using this molecular design is proposed.

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Dates: Date issued: 2012-09

Publication Status: Issued

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Identifiers: URI: http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1470/pdf
DOI: 10.1002/cmmi.1470
BibTex Citekey: KelirisMHLSE2012

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Title: Contrast Media and Molecular Imaging

Source Genre: Journal

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Pages: - Volume / Issue: 7 (5) Sequence Number: - Start / End Page: 478–483 Identifier: -