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Abstract:
The presented paper addresses the optimization of isothermal preferential crystallization for separation of pure enantiomer from racemic mixtures. The optimization uses a rigorous process model. A sequence of stochastic and deterministic minimization algorithms are used. Optimized are the initial values of mass of racemate, mass of seeds and mean seed size. The approach is illustrated by a case study for amino acid L-/D-threonine. A promising cyclic operation mode is discussed. Although the results are not validated experimentally, the aim of this work is increase the applicability of the process.
© 2006 American Chemical Society [accessed 2013 November 27th]