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Free keywords:
continuous countercurrent chromatography; feasibility; optimization
Abstract:
This paper introduces an exact mathematical approach based on combinatorial optimization to analyze continuous linear countercurrent chromatographic processes. The analysis is based on a given set of input parameters including, in particular, purity requirements and number of plates per zone. As an outcome of the analysis either a proof of infeasibility is derived for a given set of parameters, or a feasible solution is found that is in correspondence with the input requirements. Details regarding the mathematical combinatorial subproblems are presented.
Copyright © 2013 Elsevier B.V. [accessed 2013 November 26th]