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  Brownian diffusion of ion channels in different membrane patch geometries

Wei, F., Yang, D., Straube, R., & Shuai, J. (2011). Brownian diffusion of ion channels in different membrane patch geometries. Physical review E, 83(2), 021919. doi:10.1103/PhysRevE.83.021919.

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 Creators:
Wei, F.1, Author
Yang, D.1, Author
Straube, R.2, Author           
Shuai, J.1, Author
Affiliations:
1Xiamen UniversityDepartment of Physics - Inst. of Theoretical PhysicsChina, ou_persistent22              
2Analysis and Redesign of Biological Networks, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738139              

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 Abstract: We asymptotically calculate the spatially averaged mean first passage time (MFPT) of a diffusing channel protein in a finite membrane patch containing a small absorbing anchor site. Different two-dimensional membrane geometries are considered including a circular, a square-shaped, a rectangular, and a cylindrical domain. The asymptotic expressions are found to be in excellent agreement with results from Monte Carlo simulations if the radius of the diffusing protein is sufficiently small. For a larger radius, a simple correction to the asymptotic expressions is proposed. We show that the average MFPT for a circle and a square-shaped domain of the same area are approximately equal as long as the anchor site is close to the center of the domain. We also discuss how the average MFPT depends on the aspect ratio of a rectangular and a cylindrical domain. Among such domains with a fixed area, a minimal MFPT is obtained for the square-shaped domain. ©2011 American Physical Society [accessed 2013 July 2nd]

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Language(s): eng - English
 Dates: 2011
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 557109
Other: 6/11
DOI: 10.1103/PhysRevE.83.021919
 Degree: -

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Title: Physical review E
Source Genre: Journal
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Publ. Info: Melville, NY : Published by the American Physical Society through the American Institute of Physics
Pages: - Volume / Issue: 83 (2) Sequence Number: - Start / End Page: 021919 Identifier: ISSN: 1539-3755
CoNE: https://pure.mpg.de/cone/journals/resource/954925225012