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How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?

Carrondo, M. J. T., Alves, P. M., Carinhas, N., Glassey, J., Hesse, F., Merten, O.-W., et al. (2012). How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal, 7(12), 1522-1529. doi:10.1002/biot.201200226.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-8A58-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-A70E-D

Genre: Journal Article

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Carrondo, Manuel J. T.^{1, 2}, Author
Alves, Paula M.^{1, 2}, Author
Carinhas, Nuno^{1, 2}, Author
Glassey, Jarka³, Author
Hesse, Friedemann⁴, Author
Merten, Otto-Wilhelm⁵, Author
Micheletti, Martina⁶, Author
Noll, Thomas⁷, Author
Oliveira, Rui^{1, 8}, Author
Reichl, Udo^{9, 10}, Author
Staby, Arne¹¹, Author
Teixeira, Ana P^{1, 2}, Author
Weichert, Henry¹², Author
Mandenius, Carl-Fredrik¹, Author

Affiliations:
1Instituto de Biologia Experimental e Tecnológica (IBET), Oeiras, Portugal, ou_persistent22
2Instituto de Tecnologia Química e Bioquímica (ITQB), Universidade Nova de Lisboa, Oeiras, Portugal, ou_persistent22
3Newcastle University, Newcastle upon Tyne, UK, ou_persistent22
4University of Applied Sciences, Biberach, Germany, ou_persistent22
5Généthon, Evry, France, ou_persistent22
6University College London, London, UK, ou_persistent22
7University of Bielefeld, Bielefeld, Germany, ou_persistent22
8Faculdade de Ciˆncias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, ou_persistent22
9Otto-von-Guericke-Universität Magdeburg, ou_1738156
10Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738140
11Novo Nordisk A/S, Gentofte, Denmark and Lund University, Lund, Sweden, ou_persistent22
12Sartorius Stedim Biotech GmbH, Göttingen, Germany, ou_persistent22

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Abstract: This report highlights the potential of measurement, monitoring, modeling and control (M(3) C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M(3) C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M(3) C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M(3) C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods. Copyright © 1999–2013 John Wiley & Sons, Inc. All Rights Reserved. [accessed January 10th 2013]

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Language(s): eng - English

Dates: Date issued: 2012

Publication Status: Issued

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Rev. Type: Peer

Identifiers: eDoc: 626292
DOI: 10.1002/biot.201200226

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Title: Biotechnology Journal

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Source Genre: Journal

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Pages: - Volume / Issue: 7 (12) Sequence Number: - Start / End Page: 1522 - 1529 Identifier: -