English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Suppression of Conditioned Odor Approach by Feeding Is Independent of Taste and Nutritional Value in Drosophila

Gruber, F. A., Knapek, S., Fujita, M., Matsuo, K., Bräcker, L., Shinzato, N., et al. (2013). Suppression of Conditioned Odor Approach by Feeding Is Independent of Taste and Nutritional Value in Drosophila. CURRENT BIOLOGY, 23(6), 507-514. doi:10.1016/j.cub.2013.02.010.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Gruber, Franz Andreas1, Author           
Knapek, Stephan1, Author           
Fujita, Michiko2, Author
Matsuo, Koichiro2, Author
Bräcker, Lasse1, Author           
Shinzato, Nao2, Author
Siwanowicz, Igor1, Author           
Tanimura, Teiichi2, Author
Tanimoto, Hiromu1, Author           
Affiliations:
1Max Planck Research Group: Behavioral Genetics / Tanimoto, MPI of Neurobiology, Max Planck Society, ou_1113555              
2external, ou_persistent22              

Content

show
hide
Free keywords: LONG-TERM-MEMORY; ENERGY HOMEOSTASIS; MUTANT DROSOPHILA; FOOD-INTAKE; MELANOGASTER; BEHAVIOR; GROWTH; SUGAR; METABOLISM; EXPRESSION
 Abstract: Motivation controls behavior [1]. A variety of food-related behaviors undergo motivational modulation by hunger, satiety, and other states [2-4]. Here we searched for critical satiation factors modulating approach to an odor associated with sugar reward in Drosophila melanogaster. We selectively manipulated different parameters associated with feeding, such as internal glucose levels, and determined which are required for suppressing conditioned odor approach. Surprisingly, glucose levels in the hemolymph, nutritional value, sweetness of the food, and ingested volume (above a minimal threshold) did not influence behavior suppression. Instead, we found that the total osmolarity of ingested food is a critical satiation factor. In parallel, we found that conditioned approach is transiently suppressed by artificial stimulation of adipokinetic hormone (AKH) expressing corpora cardiaca cells, which causes elevation of hemolymph carbohydrate and lipid concentrations [5, 6]. This result implies that a rise in hemolymph osmolarity, without the experience of feeding, is sufficient to satiate conditioned odor approach. AKH stimulation did not affect innate sugar preference, suggesting that multiple satiation signals control different sets of appetitive behaviors.

Details

show
hide
Language(s): eng - English
 Dates: 2013
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000316430000029
DOI: 10.1016/j.cub.2013.02.010
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: CURRENT BIOLOGY
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 23 (6) Sequence Number: - Start / End Page: 507 - 514 Identifier: ISSN: 0960-9822