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  Precise Lamination of Retinal Axons Generates Multiple Parallel Input Pathways in the Tectum

Robles, E., Filosa, A., & Baier, H. (2013). Precise Lamination of Retinal Axons Generates Multiple Parallel Input Pathways in the Tectum. JOURNAL OF NEUROSCIENCE, 33(11), 5027-5039. doi:10.1523/JNEUROSCI.4990-12.2013.

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 Creators:
Robles, Estuardo1, Author           
Filosa, Alessandro1, Author           
Baier, Herwig1, Author           
Affiliations:
1Department: Genes–Circuits–Behavior / Baier, MPI of Neurobiology, Max Planck Society, ou_1128545              

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Free keywords: SUPERFICIAL SUPERIOR COLLICULUS; ZEBRAFISH OPTIC TECTUM; GANGLION-CELLS; IN-VIVO; RETINOTECTAL PROJECTION; NEURAL CIRCUIT; IV COLLAGEN; PATTERNS; REVEALS; NEURONS
 Abstract: The axons of retinal ganglion cells (RGCs) form topographic connections in the optic tectum, recreating a two-dimensional map of the visual field in the midbrain. RGC axons are also targeted to specific positions along the laminar axis of the tectum. Understanding the sensory transformations performed by the tectum requires identification of the rules that control the formation of synaptic laminae by RGC axons. However, there is little information regarding the spatial relationships between multiple axons as they establish laminar and retinotopic arborization fields within the same region of neuropil. Moreover, the contribution of RGC axon lamination to the processing of visual information is unknown. We used Brainbow genetic labeling to visualize groups of individually identifiable axons during the assembly of a precise laminar map in the larval zebrafish tectum. Live imaging of multiple RGCs revealed that axons target specific sublaminar positions during initial innervation and maintain their relative laminar positions throughout early larval development, ruling out a model for lamina selection based on iterative refinements. During this period of laminar stability, RGC arbors undergo structural rearrangements that shift their relative retinotopic positions. Analysis of cell-type-specific lamination patterns revealed that distinct combinations of RGCs converge to form each sublamina, and this input heterogeneity correlates with different functional responses to visual stimuli. These findings suggest that lamina-specific sorting of retinal inputs provides an anatomical blueprint for the integration of visual features in the tectum.

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Language(s): eng - English
 Dates: 2013
 Publication Status: Issued
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: JOURNAL OF NEUROSCIENCE
Source Genre: Journal
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Publ. Info: 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA : SOC NEUROSCIENCE
Pages: - Volume / Issue: 33 (11) Sequence Number: - Start / End Page: 5027 - 5039 Identifier: ISSN: 0270-6474