English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

Lill, C. M., Roehr, C., McQueen, M. B., Kavvoura, F. K., Bagade, S., Schjeide, B.-M., et al. (2012). Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database. PLoS Genetics, 8(3), e1002548. doi:ARTN e1002548DOI 10.1371/journal.pgen.1002548.

Item is

Files

show Files
hide Files
:
Lill.pdf (Publisher version), 685KB
Name:
Lill.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
2012
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Lill, Christina M.1, Author           
Roehr, Christina2, Author           
McQueen, M. B., Author
Kavvoura, F. K., Author
Bagade, S., Author
Schjeide, Brit-Maren1, Author           
Schjeide, Leif3, Author           
Meissner, Esther1, Author           
Zauft, Ute1, Author           
Allen, N. C., Author
Liu, Tian1, Author
Schilling, Marcel1, Author           
Anderson, K. J., Author
Beecham, G., Author
Berg, D., Author
Biernacka, J. M., Author
Brice, A., Author
DeStefano, A. L., Author
Do, C. B., Author
Eriksson, N., Author
Factor, S. A., AuthorFarrer, M. J., AuthorForoud, T., AuthorGasser, T., AuthorHamza, T., AuthorHardy, J. A., AuthorHeutink, P., AuthorHill-Burns, E. M., AuthorKlein, C., AuthorLatourelle, J. C., AuthorMaraganore, D. M., AuthorMartin, E. R., AuthorMartinez, M., AuthorMyers, R. H., AuthorNalls, M. A., AuthorPankratz, N., AuthorPayami, H., AuthorSatake, W., AuthorScott, W. K., AuthorSharma, M., AuthorSingleton, A. B., AuthorStefansson, K., AuthorToda, T., AuthorTung, J. Y., AuthorVance, J., AuthorWood, N. W., AuthorZabetian, C. P., AuthorYoung, P., AuthorTanzi, R. E., AuthorKhoury, M. J., AuthorZipp, F., AuthorLehrach, Hans3, Author           Ioannidis, J. P. A., AuthorBertram, Lars1, 2, Author           Parkinson's, Genetic Epidemiology, AuthorIPDGC, AuthorConsortium, Parkinson's Dis GWAS, AuthorWTCCC2, Author more..
Affiliations:
1Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, Ihnestr. 63-74, Berlin, Germany, ou_1479655              
2Cancer Genomics (Michal-Ruth Schweiger), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, Ihnestr. 63-74, Berlin, Germany, ou_1479649              
3Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, Ihnestr. 63- Berlin, Germany, ou_1433550              

Content

show
hide
Free keywords: genome-wide association alpha-synuclein risk-factors mutations variants susceptibility datasets trials region vps35
 Abstract: More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson’s disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensively collects and meta-analyzes all published studies in the field. A systematic literature screen of ,27,000 articles yielded 828 eligible articles from which relevant data were extracted. In addition, individual-level data from three publicly available genome-wide association studies (GWAS) were obtained and subjected to genotype imputation and analysis. Overall, we performedmeta-analyses on more than seven million polymorphisms originating either from GWAS datasets and/or from smaller scale PD association studies. Metaanalyses on 147 SNPs were supplemented by unpublished GWAS data from up to 16,452 PD cases and 48,810 controls. Eleven loci showed genome-wide significant (P,561028) association with disease risk: BST1, CCDC62/HIP1R, DGKQ/GAK, GBA, LRRK2, MAPT, MCCC1/LAMP3, PARK16, SNCA, STK39, and SYT11/RAB25. In addition, we identified novel evidence for genome-wide significant association with a polymorphism in ITGA8 (rs7077361, OR 0.88, P=1.361028). All meta-analysis results are freely available on a dedicated online database (www.pdgene.org), which is cross-linked with a customized track on the UCSC Genome Browser. Our study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies.

Details

show
hide
Language(s): eng - English
 Dates: 2011-10-162012-01-052012-03-15
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000302254800024
DOI: ARTN e1002548DOI 10.1371/journal.pgen.1002548
ISSN: 1553-7404
URI: ://WOS:000302254800024
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: PLoS Genetics
  Other : PLoS Genet.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: San Francisco, CA : Public Library of Science
Pages: 10 Volume / Issue: 8 (3) Sequence Number: - Start / End Page: e1002548 Identifier: ISSN: 1553-7390
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017180