ausblenden:
Schlagwörter:
marine furanocembranoids - asymmetric synthesis - vinylogous Mukaiyama addition - lactones - furans
Zusammenfassung:
A diastereoselective methodology for preparing trans-γ-lactone-γ-butenolides through vinylogous aldol additions of siloxyfuranes to enantiopure cyclopropylcarbaldehyde followed by a tin-catalyzed retroaldol-lactonization cascade is reported. This synthetic approach is applied to a short synthesis of an exo-trienol furan lactone substructure relevant to bielschowskysin and other related coral diterpenoid natural products.
