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  miRNA and tropism of human parvovirus B19

Berillo, O., Khailenko, V., Ivashchenko, A., Perlmuter-Shoshany, L., & Bolshoy, A. (2012). miRNA and tropism of human parvovirus B19. Computational Biology and Chemistry, 40(0), 1-6. doi:10.1016/j.compbiolchem.2012.06.002.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-E888-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-E889-D
Genre: Journal Article

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 Creators:
Berillo, Olga1, Author
Khailenko, Vladimir1, Author
Ivashchenko, Anatoly1, Author
Perlmuter-Shoshany, Lior1, Author
Bolshoy, Alexander1, Author
Affiliations:
1Max-Planck-Society, ou_persistent13              

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Free keywords: Inhibition of translation Hybridization miRNA-mRNA site prediction Codon optimization Synonymous substitutions Host–virus interactions
 Abstract: Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.

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 Dates: 2012-06-222012-10
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.compbiolchem.2012.06.002
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Title: Computational Biology and Chemistry
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 40 (0) Sequence Number: - Start / End Page: 1 - 6 Identifier: ISSN: 1476-9271