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  Characterization of herpes simplex virus type 1 L-particle assembly and egress in hippocampal neurones by electron cryo-tomography

Ibiricu, I., Maurer, U. E., & Grünewald, K. (2013). Characterization of herpes simplex virus type 1 L-particle assembly and egress in hippocampal neurones by electron cryo-tomography. CELLULAR MICROBIOLOGY, 15(2), 285-291. doi:10.1111/cmi.12093.

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Ibiricu, Iosune1, Autor           
Maurer, Ulrike Elisabeth1, Autor           
Grünewald, Kay2, Autor           
Affiliations:
1Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              
2Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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Schlagwörter: CRYOELECTRON TOMOGRAPHY; COATED VESICLES; CLATHRIN; TRANSPORT; COPI; MICROSCOPY; INFECTION; TEGUMENT; REPLICATION; MATURATION
 Zusammenfassung: Visualizing virus-host interactions in situ inside infected cells by electron cryo-tomography provides unperturbed snapshots of the infection process. Here we focus on the assembly and egress pathway of herpesviruses. Cells infected with herpes simplex virus 1 produce and release not only infective virions but also non-infectious light particles (L-particles). L-particles are devoid of viral capsids and genomes. In this study, we analysed L-particle assembly and egress pathways in cultured dissociated hippocampus neurones by electron cryo-tomography. Virion and L-particle formation occurred in close proximity, suggesting shared assembly and exit pathways. Clathrin-like coats were occasionally associated with L-particle and virion assembly sites. Further, we compared the three-dimensional ultrastructure of intracellular and extracellular L-particles and quantified their diameters and the abundance of inclusion bodies contained.

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Sprache(n): eng - English
 Datum: 2013-02
 Publikationsstatus: Erschienen
 Seiten: 7
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000314587000012
DOI: 10.1111/cmi.12093
 Art des Abschluß: -

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Titel: CELLULAR MICROBIOLOGY
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA : WILEY-BLACKWELL
Seiten: - Band / Heft: 15 (2) Artikelnummer: - Start- / Endseite: 285 - 291 Identifikator: ISSN: 1462-5814