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  Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila

Nelson, B., Freisinger, T., Ishii, K., Okado, K., Shinzawa, N., Fukumoto, S., et al. (2013). Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 430(3), 1120-1125. doi:10.1016/j.bbrc.2012.12.027.

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Nelson, Bryce1, Autor
Freisinger, Tina2, Autor           
Ishii, Kenichi1, Autor
Okado, Kiyoshi1, Autor
Shinzawa, Naoaki1, Autor
Fukumoto, Shinya1, Autor
Kanuka, Hirotaka1, Autor
Affiliations:
1external, ou_persistent22              
2Wedlich-Söldner, Roland / Cellular Dynamics and Cell Patterning, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565174              

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Schlagwörter: INNATE IMMUNE-RESPONSE; POSITIVE BACTERIAL-INFECTIONS; KAPPA-B KINASE; PEPTIDOGLYCAN-RECOGNITION; ANTIBACTERIAL DEFENSE; INDUCIBLE EXPRESSION; DEFICIENCY IMD; TOLL PATHWAY; MELANOGASTER; RELISHInfection; Bacteria; Innate immunity; Drosophila; Antimicrobial peptide;
 Zusammenfassung: Upon microbial invasion the innate immune system of Drosophila melanogaster mounts a response that comes in two distinct but complimentary forms, humoral and cellular. A screen to find genes capable of conferring resistance to the Gram-positive Staphylococcus aureus upon ectopic expression in immune response tissues uncovered imd gene. This resistance was not dependent on cellular defenses but rather likely a result of upregulation of the humoral response through increased expression of antimicrobial peptides, including a Toll pathway reporter gene drosomycin. Taken together it appears that Imd pathway is capable of playing a role in resistance to the Gram-positive S. aureus, counter to notions of traditional roles of the Imd pathway thought largely to responsible for resistance to Gram-negative bacteria. (C) 2012 Elsevier Inc. All rights reserved.

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Sprache(n): eng - English
 Datum: 2013-01-18
 Publikationsstatus: Erschienen
 Seiten: 6
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000314376100042
DOI: 10.1016/j.bbrc.2012.12.027
 Art des Abschluß: -

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Titel: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA : ACADEMIC PRESS INC ELSEVIER SCIENCE
Seiten: - Band / Heft: 430 (3) Artikelnummer: - Start- / Endseite: 1120 - 1125 Identifikator: ISSN: 0006-291X