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Free keywords:
Ratio mass-spectrometer
Elemental analyzer
Online determination
Organic-substances
Isotope
Nitrogen
Matter
Water
o-18
Abstract:
A newly developed interface coupling a CHN combustion device (elemental analyser 'EA') to an isotope ratio mass spectrometer is described and evaluated. The purpose of the device is to extend the dynamic range of delta(13)C and delta(15)N analysis from less than 2 orders of magnitude to more than 3 orders of magnitude. Carbon isotope ratio measurements of atropine as a model compound have been performed analysing between 1 mu g to 5 mg C with acceptable to excellent precision (0.6 to 0.06 parts per thousand, delta-notation). The correction due to the blank signal is critical for sample amounts smaller than 4 mu g C. The maximum sample weight is determined by the combustion capacity of the EA, Larger sample amounts are measured using dilution of a small part of the EA effluent with helium. The dilution mechanism works virtually free of isotope fractionation, Copyright (C) 1999 John Wiley & Sons, Ltd. [References: 19]
