Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Membrane TNF confers protection to acute mycobacterial infection

Fremond, C., Allie, N., Dambuza, I., Grivennikov, S. I., Yeremeev, V. V., Quesniaux, V. F. J., et al. (2005). Membrane TNF confers protection to acute mycobacterial infection. Respiratory Research, 6: 136.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel
Alternativer Titel : Respir. Res.

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Resp_Res_2005_6.pdf (Verlagsversion), 741KB
Name:
Resp_Res_2005_6.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
© 2005 Fremond et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Fremond, Cecile, Autor
Allie, Nasiema, Autor
Dambuza, Ivy, Autor
Grivennikov, Sergei I., Autor
Yeremeev, Vladimir V.1, Autor           
Quesniaux, Valerie F. J., Autor
Jacobs, Muazzam, Autor
Ryffel, Bernhard, Autor
Affiliations:
1Department of Immunology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664146              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Mycobacterium tuberculosis H37Rv, membrane TNF, TNF-deficiency, T cell recruitment, granuloma
 Zusammenfassung: Background Tumour necrosis factor (TNF) is crucial for the control of mycobacterial infection as TNF deficient (KO) die rapidly of uncontrolled infection with necrotic pneumonia. Here we investigated the role of membrane TNF for host resistance in knock-in mice with a non-cleavable and regulated allele (mem-TNF). Methods C57BL/6, TNF KO and mem-TNF mice were infected with M. tuberculosis H37Rv (Mtb at 100 CFU by intranasal administration) and the survival, bacterial load, lung pathology and immunological parameters were investigated. Bone marrow and lymphocytes transfers were used to test the role of membrane TNF to confer resistance to TNF KO mice. Results While TNF-KO mice succumbed to infection within 4–5 weeks, mem-TNF mice recruited normally T cells and macrophages, developed mature granuloma in the lung and controlled acute Mtb infection. However, during the chronic phase of infection mem-TNF mice succumbed to disseminated infection with necrotic pneumonia at about 150 days. Reconstitution of irradiated TNF-KO mice with mem-TNF derived bone marrow cells, but not with lymphocytes, conferred host resistance to Mtb infection in TNF-KO mice. Conclusion Membrane expressed TNF is sufficient to allow cell-cell signalling and control of acute Mtb infection. Bone marrow cells, but not lymphocytes from mem-TNF mice confer resistance to infection in TNF-KO mice. Long-term infection control with chronic inflammation likely disrupting TNF mediated cell-cell signalling, additionally requires soluble TNF.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2005-11-14
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 261646
ISI: 000234374600001
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Respiratory Research
  Alternativer Titel : Respir. Res.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 6 Artikelnummer: 136 Start- / Endseite: - Identifikator: ISSN: 1465-9921