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  Acid stress activation of the sigma(E) stress response in Salmonella enterica serovar Typhimurium

Muller, C., Bang, I.-S., Velayudhan, J., Karlinsey, J., Papenfort, K., Vogel, J., et al. (2009). Acid stress activation of the sigma(E) stress response in Salmonella enterica serovar Typhimurium. Molecular Microbiology, 71(5), 1228-1238.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-C100-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-C101-7
Genre: Journal Article

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Mol_Microbiol_2009_71_1228.pdf (Publisher version), 512KB
 
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 Creators:
Muller, Cécile, Author
Bang, Iel-Soo, Author
Velayudhan, Jyoti, Author
Karlinsey, Joyce, Author
Papenfort, Kai1, Author           
Vogel, Jörg1, Author           
Fang, Ferric C., Author
Affiliations:
1Max-Planck Research Group RNA Biology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664150              

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Free keywords: ESCHERICHIA-COLI; PDZ DOMAIN; ANTIOXIDANT DEFENSES; RSEA; PROTEASE;; YAEL; DEGS; PROTEOLYSIS; RPOE; ACIDIFICATION
 Abstract: The alternative sigma factor sigma(E) is activated by unfolded outer membrane proteins (OMPs) and plays an essential role in Salmonella pathogenesis. The canonical pathway of sigma(E) activation in response to envelope stress involves sequential proteolysis of the anti-sigma factor RseA by the PDZ proteases DegS and RseP. Here we show that sigma(E) in Salmonella enterica sv. Typhimurium can also be activated by acid stress. A sigma(E)-deficient mutant exhibits increased susceptibility to acid pH and reduced survival in an acidified phagosomal vacuole. Acid activation of sigma(E)-dependent gene expression is independent of the unfolded OMP signal or the DegS protease but requires processing of RseA by RseP. The RseP PDZ domain is indispensable for acid induction, suggesting that acid stress may disrupt an inhibitory interaction between RseA and the RseP PDZ domain to allow RseA proteolysis in the absence of antecedent action of DegS. These observations demonstrate a novel environmental stimulus and activation pathway for the sigma(E) regulon that appear to be critically important during Salmonella-host cell interactions.

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Language(s): eng - English
 Dates: 2009-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 439728
ISI: 000263522000013
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Title: Molecular Microbiology
Source Genre: Journal
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Pages: - Volume / Issue: 71 (5) Sequence Number: - Start / End Page: 1228 - 1238 Identifier: ISSN: 0950-382X %R 10.1111/j.1365-2958.2009.06597.x