English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection.

Schuck, S. D., Mueller, H., Kunitz, F., Neher, A., Hoffmann, H., Franken, K. L. C. M., et al. (2009). Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection. PLoS ONE, 4(5): e5590.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-C0D8-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-C0D9-2
Genre: Journal Article

Files

show Files
hide Files
:
PLoS_ONE_2009_4_e5590.pdf (Publisher version), 896KB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-000E-C0D7-6
Name:
PLoS_ONE_2009_4_e5590.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
© 2009 Schuck et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
License:
-

Locators

show

Creators

show
hide
 Creators:
Schuck, Sebastian D.1, Author           
Mueller, Henrik1, Author           
Kunitz, Frank, Author
Neher, Albert, Author
Hoffmann, Harald, Author
Franken, Kees L. C. M., Author
Repsilber, Dirk, Author
Ottenhoff, Tom H. M., Author
Kaufmann, Stefan H. E.1, Author           
Jacobsen, Marc1, Author           
Affiliations:
1Department of Immunology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664146              

Content

show
hide
Free keywords: -
 Abstract: BACKGROUND: T-cell responses against dormancy-, resuscitation-, and reactivation-associated antigens of Mycobacterium tuberculosis are candidate biomarkers of latent infection in humans. METHODOLOGY/PRINCIPAL FINDINGS: We established an assay based on two rounds of in vitro restimulation and intracellular cytokine analysis that detects T-cell responses to antigens expressed during latent M. tuberculosis infection. Comparison between active pulmonary tuberculosis (TB) patients and healthy latently M. tuberculosis-infected donors (LTBI) revealed significantly higher T-cell responses against 7 of 35 tested M. tuberculosis latency-associated antigens in LTBI. Notably, T cells specific for Rv3407 were exclusively detected in LTBI but not in TB patients. The T-cell IFNgamma response against Rv3407 in individual donors was the most influential factor in discrimination analysis that classified TB patients and LTBI with 83% accuracy using cross-validation. Rv3407 peptide pool stimulations revealed distinct candidate epitopes in four LTBI. CONCLUSIONS: Our findings further support the hypothesis that the latency-associated antigens can be exploited as biomarkers for LTBI.

Details

show
hide
Language(s): eng - English
 Dates: 2009-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 444325
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: PLoS ONE
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 4 (5) Sequence Number: e5590 Start / End Page: - Identifier: ISSN: 1932-6203