Novel recombinant BCG expressing perfringolysin O and the over-expression of 
key immunodominant antigens; pre-clinical characterization, safety and 
protection against challenge with Mycobacterium tuberculosis

Sun, Ronggai; Skeiky, Yasir A. W.; Izzo, Angelo; Dheenadhayalan, Veerabadran; Imam, Zakaria; Penn, Erica; Stagliano, Katherine; Haddock, Scott; Mueller, Stefanie; Fulkerson, John; Scanga, Charles; Grover, Ajay; Derrick, Steven C.; Morris, Sheldon; Hone, David M.; Horwitz, Marcus A.; Kaufmann, Stefan H. E.; Sadoff, Jerald C.

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Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis

Sun, R., Skeiky, Y. A. W., Izzo, A., Dheenadhayalan, V., Imam, Z., Penn, E., et al. (2009). Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis. Vaccine, 27(33), 4412-4423.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-C0C4-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-C0C5-E

Genre: Journal Article

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Creators:
Sun, Ronggai, Author
Skeiky, Yasir A. W., Author
Izzo, Angelo, Author
Dheenadhayalan, Veerabadran, Author
Imam, Zakaria, Author
Penn, Erica, Author
Stagliano, Katherine, Author
Haddock, Scott, Author
Mueller, Stefanie, Author
Fulkerson, John, Author
Scanga, Charles, Author
Grover, Ajay, Author
Derrick, Steven C., Author
Morris, Sheldon, Author
Hone, David M., Author
Horwitz, Marcus A., Author
Kaufmann, Stefan H. E.¹, Author
Sadoff, Jerald C., Author

Affiliations:
1Department of Immunology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664146

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Free keywords: Recombinant BCG; Endosome lysis; Antigen over-expression; Ad35;; Prime-boost; Tuberculosis; Vaccination; T-cell; Protection; GUINEA-PIG MODEL; IMMUNODEFICIENCY-VIRUS-INFECTION; MAJOR SECRETORY; PROTEIN; CD8(+) T-CELLS; PULMONARY TUBERCULOSIS; IMMUNE-RESPONSES;; SUBUNIT VACCINE; INTERFERON-GAMMA; BOVIS BCG; EXTRACELLULAR PROTEINS

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Language(s): eng - English

Dates: Date issued: 2009-07

Publication Status: Issued

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Identifiers: eDoc: 436553
ISI: 000268217600005

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Title: Vaccine

Source Genre: Journal

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Pages: - Volume / Issue: 27 (33) Sequence Number: - Start / End Page: 4412 - 4423 Identifier: ISSN: 0264-410X %R 10.1016/j.vaccine.2009.05.048