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  Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation

Seiler, K., Tsuneto, M., & Melchers, F. (2011). Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation. Journal of Biomedicine and Biotechnology, 895086. doi:10.1155/2011/895086.

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Genre: Journal Article
Alternative Title : J. Biomed. Biotechnol.

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J_Biomed_Biotechnol_2011_895086.pdf (Publisher version), 524KB
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J_Biomed_Biotechnol_2011_895086.pdf
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© 2011 Katharina Seiler et al.
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 Creators:
Seiler, Katharina1, Author           
Tsuneto, Motokazu1, Author           
Melchers, Fritz1, Author           
Affiliations:
1Max-Planck Fellowship Lymphocyte Development, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664148              

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 Abstract: We review here our experiences with the in vitro reprogramming of somatic cells to induced pluripotent stem cells (iPSC) and subsequent in vitro development of hematopoietic cells from these iPSC and from embryonic stem cells (ESC). While, in principle, the in vitro reprogramming and subsequent differentiation can generate hematopoietic cell from any somatic cells, it is evident that many of the steps in this process need to be significantly improved before it can be applied to human cells and used in clinical settings of hematopoietic stem cell (HSC) transplantations.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 581623
ISI: 000298751200001
DOI: 10.1155/2011/895086
 Degree: -

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Title: Journal of Biomedicine and Biotechnology
  Alternative Title : J. Biomed. Biotechnol.
Source Genre: Journal
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Publ. Info: NEW YORK : HINDAWI PUBLISHING CORPORATION
Pages: - Volume / Issue: - Sequence Number: 895086 Start / End Page: - Identifier: ISSN: 1110-7243