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  The volatiles of pathogenic and nonpathogenic mycobacteria and related bacteria

Nawrath, T., Mgode, G. F., Weetjens, B., Kaufmann, S. H. E., & Schulz, S. (2012). The volatiles of pathogenic and nonpathogenic mycobacteria and related bacteria. Beilstein Journal of Organic Chemistry, 8, 290-299. doi:10.3762/bjoc.8.31.

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Genre: Zeitschriftenartikel
Alternativer Titel : Beilstein J. Org. Chem.

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Beilstein_J_Org_Chem_2011_8_290.pdf (Verlagsversion), 284KB
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© 2012, Nawrath et al; licensee Beilstein-Institut.
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 Urheber:
Nawrath, Thorben, Autor
Mgode, Georgies F.1, Autor           
Weetjens, Bart, Autor
Kaufmann, Stefan H. E.1, Autor           
Schulz, Stefan, Autor
Affiliations:
1Department of Immunology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664146              

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Schlagwörter: aromatic compounds; CLSA; terpenes; tuberculosis; volatile profile
 Zusammenfassung: Volatiles released by pathogenic and nonpathogenic mycobacteria, as well as by mycobacteria-related Nocardia spp., were analyzed. Bacteria were cultivated on solid and in liquid media, and headspace samples were collected at various times during the bacterial lifecycle to elucidate the conditions giving optimal volatile emission. Emitted volatiles were collected by using closed-loop stripping analysis (CLSA) and were analyzed by gas-chromatography-mass-spectrometry. A wide range of compounds was produced, although the absolute amount was small. Nevertheless, characteristic bouquets of compounds could be identified. Predominantly aromatic compounds and fatty-acid derivatives were released by pathogenic/nonpathogenic mycobacteria, while the two Nocardia spp. (N. asteroides and N. africana) emitted the sesquiterpene aciphyllene. Pathogenic Mycobacterium tuberculosis strains grown on agar plates produced a distinct bouquet with different volatiles, while liquid cultures produce less compounds but sometimes an earlier onset of volatile production because of their steeper growth curves under this conditions. This behavior differentiates M. tuberculosis from other mycobacteria, which generally produced fewer compounds in seemingly lower amounts. Knowledge of the production of volatiles by M. tuberculosis can facilitate the rational design of alternative and faster diagnostic measures for tuberculosis.

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Sprache(n): eng - English
 Datum: 2012-02-22
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 608896
ISI: 000300713900001
DOI: 10.3762/bjoc.8.31
 Art des Abschluß: -

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Titel: Beilstein Journal of Organic Chemistry
  Alternativer Titel : Beilstein J. Org. Chem.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: FRANKFURT AM MAIN : BEILSTEIN-INSTITUT
Seiten: - Band / Heft: 8 Artikelnummer: - Start- / Endseite: 290 - 299 Identifikator: ISSN: 1860-5397