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  Immunity to Intracellular Salmonella Depends on Surface-associated Antigens

Barat, S., Willer, Y., Rizos, K., Claudi, B., Mazé, A., Schemmer, A. K., et al. (2012). Immunity to Intracellular Salmonella Depends on Surface-associated Antigens. PLoS Pathogens, 8(10): e1002966. doi:10.1371/journal.ppat.1002966.

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Genre: Zeitschriftenartikel
Alternativer Titel : PLoS Pathog.

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PLoS_Pathogens_2012_8_e1002966.pdf (Verlagsversion), 864KB
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Barat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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 Urheber:
Barat, Somedutta, Autor
Willer, Yvonne, Autor
Rizos, Konstantin1, Autor           
Claudi, Beatrice, Autor
Mazé, Alain, Autor
Schemmer, Anne K., Autor
Kirchhoff, Dennis, Autor
Schmidt, Alexander, Autor
Burton, Neil, Autor
Bumann, Dirk1, Autor           
Affiliations:
1Department of Molecular Biology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664147              

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 Zusammenfassung: Invasive Salmonella infection is an important health problem that is worsening because of rising antimicrobial resistance and changing Salmonella serovar spectrum. Novel vaccines with broad serovar coverage are needed, but suitable protective antigens remain largely unknown. Here, we tested 37 broadly conserved Salmonella antigens in a mouse typhoid fever model, and identified antigen candidates that conferred partial protection against lethal disease. Antigen properties such as high in vivo abundance or immunodominance in convalescent individuals were not required for protectivity, but all promising antigen candidates were associated with the Salmonella surface. Surprisingly, this was not due to superior immunogenicity of surface antigens compared to internal antigens as had been suggested by previous studies and novel findings for CD4 T cell responses to model antigens. Confocal microscopy of infected tissues revealed that many live Salmonella resided alone in infected host macrophages with no damaged Salmonella releasing internal antigens in their vicinity. In the absence of accessible internal antigens, detection of these infected cells might require CD4 T cell recognition of Salmonella surface-associated antigens that could be processed and presented even from intact Salmonella. In conclusion, our findings might pave the way for development of an efficacious Salmonella vaccine with broad serovar coverage, and suggest a similar crucial role of surface antigens for immunity to both extracellular and intracellular pathogens.

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Sprache(n): eng - English
 Datum: 2012-10
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 629453
ISI: 000310530300029
DOI: 10.1371/journal.ppat.1002966
 Art des Abschluß: -

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Titel: PLoS Pathogens
  Alternativer Titel : PLoS Pathog.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: SAN FRANCISCO : PUBLIC LIBRARY SCIENCE
Seiten: - Band / Heft: 8 (10) Artikelnummer: e1002966 Start- / Endseite: - Identifikator: ISSN: 1553-7374