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  Protein Kinase C-beta-Dependent Activation of NF-kappa B in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo

Lutzny, G., Kocher, T., Schmidt-Supprian, M., Rudelius, M., Klein-Hitpass, L., Finch, A. J., et al. (2013). Protein Kinase C-beta-Dependent Activation of NF-kappa B in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo. CANCER CELL, 23(1), 77-92. doi:10.1016/j.ccr.2012.12.003.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-B247-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-B248-6
Genre: Journal Article

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 Creators:
Lutzny, Gloria1, Author
Kocher, Thomas1, Author
Schmidt-Supprian, Marc2, Author           
Rudelius, Martina1, Author
Klein-Hitpass, Ludger1, Author
Finch, Andrew J.1, Author
Duerig, Jan1, Author
Wagner, Michaela1, Author
Haferlach, Claudia1, Author
Kohlmann, Alexander1, Author
Schnittger, Susanne1, Author
Seifert, Marc1, Author
Wanninger, Stefan1, Author
Zaborsky, Nadja1, Author
Oostendorp, Robert1, Author
Ruland, Juergen1, Author
Leitges, Michael1, Author
Kuhnt, Toni1, Author
Schaefer, Yvonne1, Author
Lampl, Benedikt1, Author
Peschel, Christian1, AuthorEgle, Alexander1, AuthorRingshausen, Ingo1, Author more..
Affiliations:
1external, ou_persistent22              
2Schmidt-Supprian, Marc / Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565167              

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Free keywords: DEFICIENT MICE; EXPRESSION; CANCER; APOPTOSIS; MOUSE; CLL; MODEL; MALIGNANCIES; DEGRADATION; RECRUITMENT
 Abstract: Tumor cell survival critically depends on heterotypic communication with benign cells in the microenvironrnent. Here, we describe a survival signaling pathway activated in stromal cells by contact to B cells from patients with chronic lymphocytic leukemia (CLL). The expression of protein kinase C (PKC)-beta II and the subsequent activation of NF-kappa B in bone marrow stromal cells are prerequisites to support the survival of malignant B cells. PKC-beta knockout mice are insusceptible to CLL transplantations, underscoring the in vivo significance of the PKC-beta II-NF-kappa B signaling pathway in the tumor microenvironment. Upregulated stromal PKG-beta II in biopsies from patients with CLL, acute lymphoblastic leukemia, and mantle cell lymphoma suggests that this pathway may commonly be activated in a variety of hematological malignancies.

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Language(s): eng - English
 Dates: 2013
 Publication Status: Issued
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000313759100009
DOI: 10.1016/j.ccr.2012.12.003
 Degree: -

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Title: CANCER CELL
Source Genre: Journal
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Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 23 (1) Sequence Number: - Start / End Page: 77 - 92 Identifier: ISSN: 1535-6108