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  Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: Implications for pathogenesis of affective disorders

Keck, M., Wigger, A., Welt, T., Müller, M., Gesing, A., Reul, J., et al. (2002). Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: Implications for pathogenesis of affective disorders. Neuropsychopharmacology, 26(1), 94-105.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A26F-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A270-9
Genre: Journal Article
Alternative Title : Neuropsychopharmacology

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 Creators:
Keck, ME1, Author
Wigger, A1, Author
Welt, T1, Author
Müller, MB1, Author
Gesing, A1, Author
Reul, JMHM1, Author
Holsboer, F1, Author
Landgraf, R1, Author
Neumann, ID1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: ACTH; anxiety; corticotropin-releasing hormone; depression; HAB; paraventricular nucleus
 Abstract: To investigate the neuroendocrine alterations linked to inborn emotionality in two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior, we administered the combined dexamethasone (DEX)/corticotropin- releasing hormone (CRH) test. DEX (12:00 M. (noon); 30 mug/kg) resulted in a significantly less efficient suppression of the diurnal increase in the circulating corticotropin (ACTH) levels in the male HAB rats than in the male LAB rats. In addition, plasma ACTH and corticosterone responses to subsequent CRH (7.30 P.M.; 50 ng/kg) were significantly higher in male HAB rats. The rise in ACTH after CRH in the DEX-pretreated male HAB rats points toward an enhanced activity and involvement of endogenous vasopressin synthesized in the hypothalamic paraventricular nucleus (PVN) and acting at pituitary corticotrope cells. We tested this hypothesis by in situ hybridization and in vivo microdialysis, and found an increase in both basal synthesis and release of vasopressin within the PVN of the male HAB rats. As expected, pretreatment with a Selective vasopressin type I receptor antagonist abolished the CRH-stimulated increase in ACTH secretion in the DEX-pretreated male HAB rats. The results indicate that vasopressin-mediated effects are critically involved in the profound disturbance of the hypothalamic-pituitary-adrenocortical system in male HAB rats, thus revealing striking parallels to the neuroendocrine situation in human depression. [Neuropsychopharmacology 26:94- 105,2002] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science I

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Language(s): eng - English
 Dates: 2002-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4211
ISI: 000172895100010
 Degree: -

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Title: Neuropsychopharmacology
  Alternative Title : Neuropsychopharmacology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 26 (1) Sequence Number: - Start / End Page: 94 - 105 Identifier: ISSN: 0893-133X